Shrinkage in size of the cell by loss of cell substance is known as Atrophy. Atrophy can be physiologic or pathologic. The common causes of atrophy are the following:
1. Decreased workload (atrophy of disuse).
2. Loss of innervation (denervation atrophy).
3. Diminished blood supply.
4. Inadequate nutrition.
5. Loss of endocrine stimulation.
6. Aging (senile atrophy).
7. Tissue pressure.
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