A variety of phenomena in the inflammatory response are mediated by three interrelated plasma-derived factors: the complement, kinin, and clotting systems.
Complement System:
The complement system consists of 20 component proteins, which are found in greatest concentration in plasma. This system functions in both innate and adaptive immunity for defense against microbial agents, culminating in lysing microbes by the so-called membrane attack complex (MAC).
Kinin System:
This system generates vasoactive peptides from plasma proteins called kininogens by specific proteases called kallikreins. The kinin system results in the ultimate release of the vasoactive nonapeptide bradykinin, a potent agent that increases vascular permeability.
Clotting System:
The clotting system and inflammation are intimately connected processes. The clotting system is divided into two pathways that converge, culminating in the activation of thrombin and the formation of fibrin.
8:42 AM
Subscribe to:
Post Comments (Atom)
0 comments:
Post a Comment